Improvement of NK Cell Cytotoxicity in Reconstituting NK Cells after Allogeneic Stem Cell Transplantation by Blocking NKG2A Checkpoint

Background: One cause of tumor relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the alteration of the graft-versus-tumor effect of early reconstituting natural killer (NK) cells due to overexpression of the NKG2A inhibitory receptor. This study aims to determine the ef...

Full description

Bibliographic Details
Published in:	Middle East Journal of Cancer
Main Authors:	Mohammed Taha, Cyril Fauriat
Format:	Article
Language:	English
Published:	Shiraz University of Medical Sciences 2023-10-01
Subjects:	natural killer cells monalizumab nkg2a cell cytotoxicity allogeneic hematopoietic stem cell transplantation
Online Access:	https://mejc.sums.ac.ir/article_49288_c34d602f3ba78ba602d07e535ffb28c8.pdf

Similar Items

Endothelial cells express NKG2D ligands and desensitize antitumor NK responses
by: Thornton W Thompson, et al.
Published: (2017-12-01)

Disruption of the NKG2A:HLA-E Immune Checkpoint Axis to Enhance NK Cell Activation against Cancer
by: Jack G. Fisher, et al.
Published: (2022-11-01)

Safety and Feasibility of Blockade of NK Group-2 Member-A Receptor in Natural Killer Cells Combined with Cetuximab Antibody in Patients with Advanced Gastric Adenocarcinoma
by: Maryam Samareh-Salavatipour, et al.
Published: (2025-04-01)

Elevated levels of cell-free NKG2D-ligands modulate NKG2D surface expression and compromise NK cell function in severe COVID-19 disease
by: Daniel Fernández-Soto, et al.
Published: (2024-02-01)

The NKG2D/NKG2DL Axis in the Crosstalk Between Lymphoid and Myeloid Cells in Health and Disease
by: Ana Stojanovic, et al.
Published: (2018-04-01)

More balance toward activating receptors and cytotoxic activity of NK cells ex vivo differentiated from human umbilical cord blood-derived CD34+ stem cells in comparison with peripheral blood NK cells
by: Farhoodeh Ghaedrahmati, et al.
Published: (2024-08-01)

NK cell education: Physiological and pathological influences
by: Philippe Rascle, et al.
Published: (2023-01-01)

Impact of Early Natural Killer Cell Reconstitution on the Outcomes of T Cell-Replete Allogeneic Hematopoietic Stem Cell Transplantation
by: Zhou Z, et al.
Published: (2023-07-01)

Exploring the dynamic of NKG2D/NKG2DL axis: A central regulator of NK cell functions
by: Caterina Marangio, et al.
Published: (2025-05-01)

Human Cytomegalovirus Antigen Presentation by HLA-DR+ NKG2C+ Adaptive NK Cells Specifically Activates Polyfunctional Effector Memory CD4+ T Lymphocytes
by: Marcel Costa-García, et al.
Published: (2019-04-01)

Natural Killer (NK) Cell Education Differentially Influences HIV Antibody-Dependent NK Cell Activation and Antibody-Dependent Cellular Cytotoxicity
by: Nicole F. Bernard, et al.
Published: (2017-08-01)

Responsiveness to Influenza Vaccination Correlates with NKG2C-Expression on NK Cells
by: Peggy Riese, et al.
Published: (2020-06-01)

KLRC1 knockout overcomes HLA-E-mediated inhibition and improves NK cell antitumor activity against solid tumors
by: Alice Mac Donald, et al.
Published: (2023-08-01)

Directed Differentiation of Mobilized Hematopoietic Stem and Progenitor Cells into Functional NK Cells with Enhanced Antitumor Activity
by: Pranav Oberoi, et al.
Published: (2020-03-01)

CD56 regulates human NK cell cytotoxicity through Pyk2
by: Justin T Gunesch, et al.
Published: (2020-06-01)

PD-1 is expressed in cytotoxic granules of NK cells and rapidly mobilized to the cell membrane following recognition of tumor cells
by: Cecilia Pesini, et al.
Published: (2022-12-01)

CRISPR-Cas9 based gene editing of the immune checkpoint NKG2A enhances NK cell mediated cytotoxicity against multiple myeloma
by: Tobias Bexte, et al.
Published: (2022-12-01)

Enhancing a Natural Killer: Modification of NK Cells for Cancer Immunotherapy
by: Rasa Islam, et al.
Published: (2021-04-01)

Natural Killer (NK) Cell Alloreactivity in Haploidentical Stem Cell Transplantation
by: Mar Luis-Hidalgo, et al.
Published: (2025-07-01)

Increased proliferative response of highly differentiated CD57<sup>+</sup>NKG2C<sup>+</sup>NK cells expressing NKG2A
by: N. A. Alekseeva, et al.
Published: (2024-09-01)

Altered ganglioside GD3 in HeLa cells might influence the cytotoxic abilities of NK cells
by: Wen-Chi Lee, et al.
Published: (2012-06-01)

Dual Targeting of Glioblastoma Cells with Bispecific Killer Cell Engagers Directed to EGFR and ErbB2 (HER2) Facilitates Effective Elimination by NKG2D-CAR-Engineered NK Cells
by: Anne Kiefer, et al.
Published: (2024-01-01)

Downregulation of MCT4 for lactate exchange promotes the cytotoxicity of NK cells in breast carcinoma
by: Yaping Long, et al.
Published: (2018-09-01)

Cell Therapy Using Anti-NKG2A Pretreated Natural Killer Cells in Patients with Hepatocellular Carcinoma
by: Shirin Tavakoli, et al.
Published: (2024-12-01)

Allogeneic NKG2D CAR-T Cell Therapy: A Promising Approach for Treating Solid Tumors
by: Sabir A. Mukhametshin, et al.
Published: (2025-09-01)

Blocking NKG2A in Echinococcus multilocularis infection partially relieves impairment of NK cell function of the host
by: Ayinuer Aierken, et al.
Published: (2025-08-01)

Differential Effects of Histone Deacetylases on the Expression of NKG2D Ligands and NK Cell-Mediated Anticancer Immunity in Lung Cancer Cells
by: Haeryung Cho, et al.
Published: (2021-06-01)

Increased concentration of sialidases by HeLa cells might influence the cytotoxic ability of NK cells
by: Wen-Chi Lee, et al.
Published: (2012-06-01)

Isolation of a cytolytic subpopulation of extracellular vesicles derived from NK cells containing NKG7 and cytolytic proteins
by: Miriam Aarsund, et al.
Published: (2022-09-01)

Human Metapneumovirus Escapes NK Cell Recognition through the Downregulation of Stress-Induced Ligands for NKG2D
by: Mohammad Diab, et al.
Published: (2020-07-01)

Romidepsin Enhances the Killing Ability of NKG2D-CAR-T Cells through Enhanced Expression of NKG2DL against Ovarian Cancer Cells
by: Liang Wang, et al.
Published: (2022-09-01)

Reconstituting NK Cells After Allogeneic Stem Cell Transplantation Show Impaired Response to the Fungal Pathogen Aspergillus fumigatus
by: Esther Weiss, et al.
Published: (2020-09-01)

Autophagy-mediated NKG2D internalization impairs NK cell function and exacerbates radiation pneumonitis
by: Ruiqing Wang, et al.
Published: (2023-11-01)

Expression features of CD16 and NKG2D receptors by NK cells, NKT cells and T lymphocytes of peripheral blood associated with female infertility
by: V. A. Mikhailova, et al.
Published: (2025-07-01)

Significance of HLA-E and its two NKG2 receptors in development of complications after allogeneic transplantation of hematopoietic stem cells
by: Jagoda Siemaszko, et al.
Published: (2023-10-01)

Enhancing cord blood stem cell-derived NK cell growth and differentiation through hyperosmosis
by: Wei Wen, et al.
Published: (2023-10-01)

Influence of KIR and NK Cell Reconstitution in the Outcomes of Hematopoietic Stem Cell Transplantation
by: Fei Gao, et al.
Published: (2020-09-01)

Two major human phenotypes of MICA molecules and their differential activation to NK cells via NKG2D receptor
by: Qizhi Luo, et al.
Published: (2025-05-01)

Bloodstream infections in different stage of reconstitution after first allogeneic hematopoietic stem cell transplantation
by: M. I. Akhmedov, et al.
Published: (2022-01-01)

Attenuation of natural killer cell cytotoxicity by interaction between NKp30 of NK cells and dipeptidase 1 of colon cancer cells
by: Jong-Tae Kim, et al.
Published: (2025-10-01)