Single-cell transcriptomics reveals the cellular identity of a novel progenitor population crucial for murine neural tube closure

Neural tube closure in vertebrates is achieved through a highly dynamic and coordinated series of morphogenic events involving neuroepithelium, surface ectoderm, and neural plate border. Failure of this process in the caudal region causes spina bifida. Grainyhead-like 3 (GRHL3) is an indispensable t...

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Bibliographic Details

Published in:	Heliyon
Main Authors:	Zihao Deng, Marina R. Carpinelli, Tariq Butt, Graham W. Magor, Peinan Zhao, Kevin R. Gillinder, Andrew C. Perkins, Stephen M. Jane
Format:	Article
Language:	English
Published:	Elsevier 2024-09-01
Subjects:	Grhl3 Tfap2a Tfap2c Neural tube closure Neural tube defects Single cell-RNA sequencing
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405844024132902