Case report: Application of targeted NGS for the detection of non-canonical driver variants in MPN

Background: JAK2, CALR, and MPL gene mutations are recognized as driver mutations of myeloproliferative neoplasms (MPNs). MPNs without these mutations are called triple-negative (TN) MPNs. Recently, novel mutation loci were continuously discovered using next-generation sequencing (NGS), along with c...

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Bibliographic Details

Published in:	Frontiers in Genetics
Main Authors:	Jin Zhang, Kefeng Shen, Min Xiao, Jinjin Huang, Jin Wang, Yaqin Wang, Zhenya Hong
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-06-01
Subjects:	triple-negative myeloproliferative neoplasm next-generation sequencing JAK2 CALR MPL SH2B3
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2023.1198834/full