A zebrafish and mouse model for selective pruritus via direct activation of TRPA1

Little is known about the capacity of lower vertebrates to experience itch. A screen of itch-inducing compounds (pruritogens) in zebrafish larvae yielded a single pruritogen, the TLR7 agonist imiquimod, that elicited a somatosensory neuron response. Imiquimod induced itch-like behaviors in zebrafish...

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Bibliographic Details
Published in:eLife
Main Authors: Kali Esancy, Logan Condon, Jing Feng, Corinna Kimball, Andrew Curtright, Ajay Dhaka
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-03-01
Subjects:
itch
pain
TRPA1
somatosensory
imiquimod
Online Access:https://elifesciences.org/articles/32036

Internet

https://elifesciences.org/articles/32036

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