Association between Fluoxetine Use and Overall Survival among Patients with Cancer Treated with PD-1/L1 Immunotherapy

Checkpoint inhibitors can be a highly effective antitumor therapy but only to a subset of patients, presumably due to immunotherapy resistance. Fluoxetine was recently revealed to inhibit the NLRP3 inflammasome, and NLRP3 inhibition could serve as a target for immunotherapy resistance. Therefore, we...

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Bibliographic Details
Published in:Pharmaceuticals
Main Authors: Joseph Magagnoli, Siddharth Narendran, Felipe Pereira, Tammy H. Cummings, James W. Hardin, S. Scott Sutton, Jayakrishna Ambati
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Subjects:
checkpoint inhibitors
NLRP3
PD-1/L1 immunotherapy
fluoxetine
Online Access:https://www.mdpi.com/1424-8247/16/5/640

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https://www.mdpi.com/1424-8247/16/5/640

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