The MOBSTER R package for tumour subclonal deconvolution from bulk DNA whole-genome sequencing data

Abstract Background The large-scale availability of whole-genome sequencing profiles from bulk DNA sequencing of cancer tissues is fueling the application of evolutionary theory to cancer. From a bulk biopsy, subclonal deconvolution methods are used to determine the composition of cancer subpopulati...

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Bibliographic Details

Published in:	BMC Bioinformatics
Main Authors:	Giulio Caravagna, Guido Sanguinetti, Trevor A. Graham, Andrea Sottoriva
Format:	Article
Language:	English
Published:	BMC 2020-11-01
Subjects:	Tumour subclonal deconvolution Cancer evolution Population genetics Dirichlet mixture model Whole-genome DNA sequencing
Online Access:	http://link.springer.com/article/10.1186/s12859-020-03863-1