Itaconic acid induces angiogenesis and suppresses apoptosis via Nrf2/autophagy to prolong the survival of multi-territory perforator flaps

Background: Perforator flaps are widely used in hand microsurgery to reconstruct and repair soft tissue injuries. However, ischemia and subsequent ischemia-reperfusion injury may cause distal necrosis of the flap. Itaconic acid (IA) is a modulator of macrophage function, which exerts anti-inflammato...

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Bibliographic Details

Published in:	Heliyon
Main Authors:	Gaojie Luo, Zekun Zhou, Chengxiong Huang, Peiyao Zhang, Nianzhe Sun, Wei Chen, Chao Deng, Xiaoxiao Li, Panfeng Wu, Juyu Tang, Liming Qing
Format:	Article
Language:	English
Published:	Elsevier 2023-07-01
Subjects:	Apoptosis Angiogenesis Autophagy Perforator flap
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405844023051174