Microvascular dysfunction across organs in heart failure with preserved ejection fraction: the PROSE-HFpEF case-control study

Abstract Background Systemic microvascular dysfunction is proposed as a key pathophysiological process in heart failure with preserved ejection fraction (HFpEF). This study compared microvasculature across vascular beds in HFpEF patients and controls. Methods This prospective, case-control study inc...

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Bibliographic Details

Published in:	Cardiovascular Diabetology
Main Authors:	Jerremy Weerts, Blanche L. M. Schroen, Arantxa Barandiarán Aizpurua, Tos T. J. M. Berendschot, Lloyd Brandts, Carroll A. B. Webers, Sami O. Simons, Steven J. R. Meex, Ronald Henry, Carla J. H. van der Kallen, Hans-Peter Brunner-La Rocca, Christian Knackstedt, Stephane R. B. Heymans, Rudolf A. de Boer, Vanessa P. M. van Empel, Alfons J. H. M. Houben
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Subjects:	Heart failure with preserved ejection fraction Diastolic heart failure Microcirculation Pathophysiology Sex differences HFpEF
Online Access:	https://doi.org/10.1186/s12933-025-02850-1