Validation and promise of a TCR mimic antibody for cancer immunotherapy of hepatocellular carcinoma

Abstract Monoclonal antibodies are at the vanguard of the most promising cancer treatments. Whereas traditional therapeutic antibodies have been limited to extracellular antigens, T cell receptor mimic (TCRm) antibodies can target intracellular antigens presented by cell surface major histocompatibi...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Chang Liu, Hong Liu, Moumita Dasgupta, Lance M. Hellman, Xiaogang Zhang, Kai Qu, Hui Xue, Yun Wang, Fenling Fan, Qi Chang, Duo Yu, Linhu Ge, Yu Zhang, Ziyou Cui, Pengbo Zhang, Bradley Heller, Hongbing Zhang, Bingyin Shi, Brian M. Baker, Cheng Liu
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-07-01
Online Access:	https://doi.org/10.1038/s41598-022-15946-5