Orai1 and Orai3 act through distinct signalling axes to promote stemness and tumorigenicity of breast cancer stem cells

Abstract Background One of major challenges in breast tumor therapy is the existence of breast cancer stem cells (BCSCs). BCSCs are a small subpopulation of tumor cells that exhibit characteristics of stem cells. BCSCs are responsible for progression, recurrence, chemoresistance and metastasis of br...

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Bibliographic Details

Published in:	Stem Cell Research & Therapy
Main Authors:	Duan Zhuo, Zhenchuan Lei, Lin Dong, Andrew Man Lok Chan, Jiacheng Lin, Liwen Jiang, Beibei Qiu, Xiaohua Jiang, Youhua Tan, Xiaoqiang Yao
Format:	Article
Language:	English
Published:	BMC 2024-08-01
Subjects:	Breast cancer stem cells Orai1 Orai3 Glycolysis
Online Access:	https://doi.org/10.1186/s13287-024-03875-1