Protective immunity induced by DNA vaccine containing TgGRA35, TgGRA42, and TgGRA43 against Toxoplasma gondii infection in Kunming mice

BackgroundToxoplasma gondii can cause congenital infection and abortion in humans and warm-blooded animals. T. gondii dense granule proteins, GRA35, GRA42, and GRA43, play a critical role in the establishment of chronic infection. However, their potential to induce protective immunity against T. gon...

Full description

Bibliographic Details
Published in:	Frontiers in Cellular and Infection Microbiology
Main Authors:	Youbo Shi, Jianbing Li, Weili Yang, Jia Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-10-01
Subjects:	Toxoplasma gondii GRA35 GRA42 GRA43 DNA vaccine protective immunity
Online Access:	https://www.frontiersin.org/articles/10.3389/fcimb.2023.1236130/full

Similar Items

Evaluation of immune protection against Toxoplasma gondii infection in mice induced by a multi-antigenic DNA vaccine containing TgGRA24, TgGRA25 and TgMIC6
by: Xu Xiao-Pei, et al.
Published: (2019-01-01)

Comparison of the performance of SAG2, GRA6, and GRA7 for serological diagnosis of Toxoplasma gondii infection in cats
by: Serges Sabukunze, et al.
Published: (2024-06-01)

Protective efficacy of Toxoplasma gondii GRA12 or GRA7 recombinant proteins encapsulated in PLGA nanoparticles against acute Toxoplasma gondii infection in mice
by: Hong-chao Sun, et al.
Published: (2023-07-01)

An in silico approach to decipher immunogenic epitopes in Toxoplasma gondii GRA1 and GRA3
by: Narges Safari, et al.
Published: (2024-01-01)

Two Toxoplasma gondii putative pore-forming proteins, GRA47 and GRA72, influence small molecule permeability of the parasitophorous vacuole
by: Mebratu A. Bitew, et al.
Published: (2024-03-01)

A combination of GRA3, GRA6 and GRA7 peptides offer a useful tool for serotyping type II and III Toxoplasma gondii infections in sheep and pigs
by: David Arranz-Solís, et al.
Published: (2024-04-01)

Evaluation of immunoprotection conferred by the subunit vaccines of GRA2 and GRA5 against acute toxoplasmosis in BALB/c mice
by: Xiao Teng eChing, et al.
Published: (2016-04-01)

The Toxoplasma gondii effector GRA83 modulates the host’s innate immune response to regulate parasite infection
by: Amara C. Thind, et al.
Published: (2023-10-01)

Comparative Performance of Recombinant GRA6, GRA7, and GRA14 for the Serodetection of <i>T. gondii</i> Infection and Analysis of IgG Subclasses in Human Sera from the Philippines
by: Rochelle Haidee Ybañez, et al.
Published: (2022-02-01)

Activation of NF-κB signaling by the dense granule protein GRA15 of a newly isolated type 1 Toxoplasma gondii strain
by: Guanghao Guo, et al.
Published: (2022-09-01)

Molecular interactions of Toxoplasma gondii dense granule 23 (GRA23) with host proteins PEX3 and TRAP1
by: Xuewei Fan, et al.
Published: (2025-05-01)

Immunogenicity and Protective Efficacy of a Recombinant <i>Toxoplasma gondii</i> GRA12 Vaccine in Domestic Cats
by: Jinru Yang, et al.
Published: (2025-08-01)

Preparation and Preliminary Application of Epitope Peptide-Based Antibody against <i>Toxoplasma gondii</i> GRA3
by: Ru Wang, et al.
Published: (2023-02-01)

GRA24-Based DNA Vaccine Prolongs Survival in Mice Challenged With a Virulent Toxoplasma gondii Strain
by: Bin Zheng, et al.
Published: (2019-03-01)

Screening of apical membrane antigen-1 (AMA1), dense granule protein-7 (GRA7) and rhoptry protein-16 (ROP16) antigens for a potential vaccine candidate against Toxoplasma gondii for chickens
by: Thabile Madlala, et al.
Published: (2023-08-01)

Preparation of colloidal gold immunochromatographic test strips for the diagnosis of Toxoplasma gondii
by: Yuanxi Shen, et al.
Published: (2020-01-01)

Design and immunological evaluation of a multi-epitope vaccine candidate against Toxoplasma gondii incorporating MIC13, GRA1, and SAG1 antigens in BALB/c mice
by: Zahra Hosseininejad, et al.
Published: (2025-09-01)

GRA86 Is a Novel Dense Granule Protein Important for Virulence and Bradyzoite Differentiation in <i>Toxoplasma gondii</i>
by: Xiao-Nan Zheng, et al.
Published: (2025-09-01)

Investigation of Toxoplasma infection in zoo animals using multispecies ELISA and GRA7 nested PCR
by: Ru-Min Liu, et al.
Published: (2022-09-01)

Live-attenuated PruΔgra72 strain of Toxoplasma gondii induces strong protective immunity against acute and chronic toxoplasmosis in mice
by: Jing Li, et al.
Published: (2024-09-01)

The critical role of Toxoplasma gondii GRA1 in nutrient salvage
by: Bolin Fan, et al.
Published: (2025-08-01)

Os dilemas estratégicos da Grã-Bretanha no século XXI
by: João Fábio Bertonha
Published: (2017-10-01)

Gra o człowieka. „Swój wśród obcych, obcy wśród swoich” Nikity Michałkowa
by: Łucja Demby
Published: (2006-12-01)

Bacillus subtilis spores displaying Toxoplasma gondii GRA12 induce immunity against acute toxoplasmosis
by: Hong-chao Sun, et al.
Published: (2025-02-01)

Cloning and expression of Toxoplasma gondii GRA-4 recombinant protein as a toxoplasmosis diagnostic kit candidate
by: Muhammad Hanafiah, et al.
Published: (2020-10-01)

Pajęcza gra miłosna, czyli o strategiach adaptacji Bernarda Bertolucciego
by: Alicja Helman
Published: (2017-12-01)

PLK:Δgra9 Live Attenuated Strain Induces Protective Immunity Against Acute and Chronic Toxoplasmosis
by: Jixu Li, et al.
Published: (2021-03-01)

O Padre Luís da Grã (1523-1609)
by: Fernando Pedreira de Castro
Published: (1969-03-01)

BIểU HIệN KHáNG NGUYÊN GRA7 CủA TOXOPLASMA GONDII TRONG Hệ THốNG PHI Tế BàO
by: Nguyen Thi Dieu Thuy, et al.
Published: (2013-05-01)

Neighbors Working Together: a <italic toggle="yes">Toxoplasma</italic> Rhoptry Protein That Facilitates Dense Granule Protein Translocation into the Host Cell
by: Gustavo Arrizabalaga
Published: (2019-08-01)

GraS is critical for chloroplast development and affects yield in rice
by: Zhi-xuan DU, et al.
Published: (2020-11-01)

Gra symulacyjna „Participatory Chinatown” jako innowacyjna metoda konsultacji społecznych dla młodzieży
by: Agnieszka Murawska
Published: (2025-02-01)

MULTI-RESPONSE OPTIMIZATION OF DIELECTRIC FLUID MIXTURE IN EDM USING GREY RELATIONAL ANALYSIS (GRA) IN TAGUCHI METHOD
by: Veniola Forestryani, et al.
Published: (2022-09-01)

Hybrid MCDM Model of ARAS -TOPSIS - GRA for Materials Selection Problem
by: abeer Eisa, et al.
Published: (2023-06-01)

Effective Amelioration of Liver Fibrosis Through Lentiviral Vector Carrying Toxoplasma gondii gra15II in Murine Model
by: Lei Liu, et al.
Published: (2018-07-01)

Os fundamentos da ruptura de relações diplomáticas entre o Brasil e a Grã-Bretanha em 1863: "A questão Christie" (II)
by: Richard Graham
Published: (1962-06-01)

Determination the Time of Toxoplasmosis among Pregnant Women by using IgG Avidity to Various Toxoplasma Gondii Antigens
by: Sanarya Tawfiq, et al.
Published: (2019-03-01)

Optimizing EDM process parameters with the use of GRA-based RSM for machining titanium alloy
by: Velusamy Mohankumar, et al.
Published: (2025-06-01)

Selection of the motivation strategy for employees in the mining industry using the GRA method
by: Janovac Tatjana, et al.
Published: (2018-01-01)

Mapping a Toxoplasma gondii interactome by crosslinking mass spectrometry and machine learning
by: Tadakimi Tomita, et al.
Published: (2025-10-01)