High-Throughput Immunogenetics Reveals a Lack of Physiological T Cell Clusters in Patients With Autoimmune Cytopenias

Autoimmune cytopenias (AIC) such as immune thrombocytopenia or autoimmune hemolytic anemia are claimed to be essentially driven by a dysregulated immune system. Using next-generation immunosequencing we profiled 59 T and B cell repertoires (TRB and IGH) of 25 newly diagnosed patients with primary or...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Donjete Simnica, Simon Schliffke, Christoph Schultheiß, Nicola Bonzanni, Lorenzo F. Fanchi, Nuray Akyüz, Barbara Gösch, Christian Casar, Benjamin Thiele, Janina Schlüter, Ansgar W. Lohse, Mascha Binder
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-08-01
Subjects:	autoimmunity AIC CLL GLIPH immunosequencing NGS
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2019.01897/full