Integrated network toxicology, machine learning, molecular docking and experimental validation to elucidate mechanism of polyethylene terephthalate microplastics inducing periodontitis

Growing evidence highlights the health risks of micro-plastics (MPs) exposure, with reported accumulations in enclosed anatomical sites such as the heart, placenta, and circulatory system. However, the role of MPs in periodontitis remains unexplored. This study employed bioinformatics, network toxic...

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Bibliographic Details

Published in:	Environment International
Main Authors:	Yaoling Han, Zhengchuan Zhang, Zijun Wang, Yiming Li, Guanhui Chen, Chen Yi, Rui Wang, Dongsheng Yu, Yi He
Format:	Article
Language:	English
Published:	Elsevier 2025-09-01
Subjects:	Polyethylene terephthalate microplastics Periodontitis Molecular docking Network toxicology Machine learning approach
Online Access:	http://www.sciencedirect.com/science/article/pii/S0160412025005355