Population pharmacokinetic and pharmacodynamic modeling of evobrutinib in healthy adult participants

Abstract Evobrutinib, a Bruton's tyrosine kinase (BTK) inhibitor, has shown therapeutic potential in relapsing multiple sclerosis. This analysis aimed to develop pharmacokinetic (PK) and pharmacodynamic (PD; BTK occupancy [BTKO]) models of evobrutinib and simulate PK and BTKO profiles under alt...

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發表在:	Clinical and Translational Science
Main Authors:	Orestis Papasouliotis, David Mitchell, Pascal Girard, Martin Dyroff
格式:	Article
語言:	英语
出版:	Wiley 2022-12-01
在線閱讀:	https://doi.org/10.1111/cts.13417