GRaNIE and GRaNPA: inference and evaluation of enhancer‐mediated gene regulatory networks

Abstract Enhancers play a vital role in gene regulation and are critical in mediating the impact of noncoding genetic variants associated with complex traits. Enhancer activity is a cell‐type‐specific process regulated by transcription factors (TFs), epigenetic mechanisms and genetic variants. Despi...

Full description

Bibliographic Details

Published in:	Molecular Systems Biology
Main Authors:	Aryan Kamal, Christian Arnold, Annique Claringbould, Rim Moussa, Nila H Servaas, Maksim Kholmatov, Neha Daga, Daria Nogina, Sophia Mueller‐Dott, Armando Reyes‐Palomares, Giovanni Palla, Olga Sigalova, Daria Bunina, Caroline Pabst, Judith B Zaugg
Format:	Article
Language:	English
Published:	Springer Nature 2023-04-01
Subjects:	enhancers gene regulatory networks macrophage biology multiomics data integration transcriptional regulation
Online Access:	https://doi.org/10.15252/msb.202311627