Crystal Structure Reveals the Full Ras–Raf Interface and Advances Mechanistic Understanding of Raf Activation

Ras and Raf-kinase interact through the Ras-binding (RBD) and cysteine-rich domains (CRD) of Raf to signal through the mitogen-activated protein kinase pathway, yet the molecular mechanism leading to Raf activation has remained elusive. We present the 2.8 Å crystal structure of the HRas–CRaf-RBD_CRD...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Trinity Cookis, Carla Mattos
Format:	Article
Language:	English
Published:	MDPI AG 2021-07-01
Subjects:	Ras Raf Raf cystein-rich domain (CRD) Ras dimerization HRas–CRaf-RBD_CRD crystal structure Ras–Raf-RBD_CRD dimer simulations
Online Access:	https://www.mdpi.com/2218-273X/11/7/996