Adipocyte Calpain‐2 Deficiency Reduces Obesity‐Accelerated Abdominal Aortic Aneurysm Formation in Mice

ABSTRACT Abdominal adiposity is associated with increased risk of abdominal aortic aneurysm (AAA) development. Calpains are non‐lysosomal calcium‐dependent cysteine proteases that are highly expressed in human and experimental AAAs. Using a pharmacological inhibitor and genetically deficient mice, w...

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Bibliographic Details

Published in:	FASEB BioAdvances
Main Authors:	Ana Clara Frony, Aida Javidan, Weihua Jiang, Michihiro Okuyama, Lihua Yang, Haruhito A. Uchida, Venkateswaran Subramanian
Format:	Article
Language:	English
Published:	Wiley 2025-10-01
Subjects:	abdominal aortic aneurysm adipocytes angiotensin II calpain obesity
Online Access:	https://doi.org/10.1096/fba.2025-00202