The role of the master cancer regulator Pin1 in the development and treatment of cancer

This review examines the complex role of Pin1 in the development and treatment of cancer. Pin1 is the only peptidyl–prolyl isomerase (PPIase) that can recognize and isomerize phosphorylated Ser/Thr-Pro peptide bonds. Pin1 catalyzes a structural change in phosphorylated Ser/Thr-Pro motifs that can mo...

詳細記述

書誌詳細

出版年:	Frontiers in Cell and Developmental Biology
主要な著者:	Robert Stewart, Shaunik Sharma, Timothy Wu, Sho Okuda, George Xie, Xiao Zhen Zhou, Brian Shilton, Kun Ping Lu
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2024-04-01
主題:	peptidyl–prolyl isomerase Pin1 inhibition cancer therapy cancer stem cells epithelial–mesenchymal transition immunosuppression
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fcell.2024.1343938/full