Determinants and Mechanisms of the Low Fusogenicity and High Dependence on Endosomal Entry of Omicron Subvariants

ABSTRACT The rapid spread and strong immune evasion of the SARS-CoV-2 Omicron subvariants has raised serious concerns for the global COVID-19 pandemic. These new variants exhibit generally reduced fusogenicity and increased endosomal entry pathway utilization compared to the ancestral D614G variant,...

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出版年:	mBio
主要な著者:	Panke Qu, John P. Evans, Chaitanya Kurhade, Cong Zeng, Yi-Min Zheng, Kai Xu, Pei-Yong Shi, Xuping Xie, Shan-Lu Liu
フォーマット:	論文
言語:	英語
出版事項:	American Society for Microbiology 2023-02-01
主題:	Omicron subvariants furin cleavage fusogenicity endosomal entry H655Y
オンライン･アクセス:	https://journals.asm.org/doi/10.1128/mbio.03176-22