Ca2+-dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapses

Summary: Long-term synaptic plasticity at glutamatergic synapses on striatal spiny projection neurons (SPNs) is central to learning goal-directed behaviors and habits. Our studies reveal that SPNs manifest a heterosynaptic, nitric oxide (NO)-dependent form of long-term postsynaptic depression of glu...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Shenyu Zhai, Shintaro Otsuka, Jian Xu, Vernon R.J. Clarke, Tatiana Tkatch, David Wokosin, Zhong Xie, Asami Tanimura, Hitesh K. Agarwal, Graham C.R. Ellis-Davies, Anis Contractor, D. James Surmeier
Format:	Article
Language:	English
Published:	Elsevier 2024-08-01
Subjects:	CP: Neuroscience
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124724008696