Steric blocking upside down: a different way of thinking about the competition between myosin and tropomyosin

At low free Ca2+, the actin binding proteins tropomyosin, troponin I, troponin T and troponin C inhibit contraction in striated muscles. Ca2+ activation alters the position of tropomyosin on actin to uncover binding sites for high affinity forms of myosin (i.e., myosin-ADP). Inhibition of contractio...

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Bibliographic Details

Published in:	Frontiers in Physics
Main Author:	Joseph M. Chalovich
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-01-01
Subjects:	steric blocking striated muscle regulation tropomyosin troponin weak binding strong binding
Online Access:	https://www.frontiersin.org/articles/10.3389/fphy.2024.1298482/full