Do common infections trigger disease-onset or -severity in CTLA-4 insufficiency?

PurposeHeterozygous mutations in CTLA4 lead to an inborn error of immunity characterized by immune dysregulation and immunodeficiency, known as CTLA-4 insufficiency. Cohort studies on CTLA4 mutation carriers showed a reduced penetrance (around 70%) and variable disease expressivity, suggesting the p...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Máté Krausz, Noriko Mitsuiki, Valeria Falcone, Johanna Komp, Sara Posadas-Cantera, Hanns-Martin Lorenz, Jiri Litzman, Daniel Wolff, Maria Kanariou, Anita Heinkele, Carsten Speckmann, Georg Häcker, Hartmut Hengel, Laura Gámez-Díaz, Bodo Grimbacher
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Subjects:	cytotoxic T-lymphocyte antigen 4 (CTLA-4) immunodeficencies immune dysregulation inborn errors of immunity (IEI) disease modifiers
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1011646/full