Pharmacophore-Based Virtual Screening and In-Silico Explorations of Biomolecules (Curcumin Derivatives) of <i>Curcuma longa</i> as Potential Lead Inhibitors of ERBB and VEGFR-2 for the Treatment of Colorectal Cancer

The newly FDA-approved drug, Axitinib, is an effective therapy against RTKs, but it possesses severe adverse effects like hypertension, stomatitis, and dose-dependent toxicity. In order to ameliorate Axitinib’s downsides, the current study is expedited to search for energetically stable and optimize...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Syeda Abida Ejaz, Mubashir Aziz, Mohamed Fawzy Ramadan, Ammara Fayyaz, Muhammad Sajjad Bilal
Format:	Article
Language:	English
Published:	MDPI AG 2023-05-01
Subjects:	pharmacophore VEGFR DFTs molecular docking molecular dynamic simulations
Online Access:	https://www.mdpi.com/1420-3049/28/10/4044