Differential metabolic alterations in IDH1 mutant vs. wildtype glioma cells promote epileptogenesis through distinctive mechanisms

Glioma-related epilepsy (GRE) is a hallmark clinical presentation of gliomas with significant impacts on patient quality of life. The current standard of care for seizure management is comprised of anti-seizure medications (ASMs) and surgical resection. Seizures in glioma patients are often drug-res...

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Bibliographic Details

Published in:	Frontiers in Cellular Neuroscience
Main Authors:	Darrian McAfee, Mitchell Moyer, Jaden Queen, Armin Mortazavi, Ujwal Boddeti, Muzna Bachani, Kareem Zaghloul, Alexander Ksendzovsky
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-11-01
Subjects:	tumor-related epilepsy brain glioma seizure development tumoral metabolism peritumoral excitability
Online Access:	https://www.frontiersin.org/articles/10.3389/fncel.2023.1288918/full