Regulation of AMPK Activity by CRBN Is Independent of the Thalidomide-CRL4^CRBN Protein Degradation Axis

Cereblon (CRBN), a primary target of immune-modulatory imide drugs (IMiDs), functions as a substrate receptor in the CUL4-RBX1-DDB1-CRBN (known as CRL4^CRBN) E3 ubiquitin ligase complex. Binding of IMiDs to CRBN redirects the CRL4^CRBN E3 ubiquitin ligase...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Seung-Joo Yang, Seungje Jeon, Jeong Won Baek, Kwang Min Lee, Chul-Seung Park
Format:	Article
Language:	English
Published:	MDPI AG 2021-05-01
Subjects:	thalidomide AMP-activated protein kinase cereblon
Online Access:	https://www.mdpi.com/1424-8247/14/6/512