Recruitment of USP10 by GCS1 to deubiquitinate GRP78 promotes the progression of colorectal cancer via alleviating endoplasmic reticulum stress

Abstract Background Long-term accumulation of misfolded proteins leads to endoplasmic reticulum (ER) stress in colorectal cancer (CRC). However, the precise pathways controlling the decision between survival and apoptosis in CRC are unclear. Therefore, in this study, we investigated the function and...

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Bibliographic Details
Published in:Journal of Experimental & Clinical Cancer Research
Main Authors: Yang Chen, Hengyang Shen, Zhenling Wang, Changzhi Huang, Hongqiang Zhang, Yu Shao, Ying Tong, Lei Xu, Yunfei Lu, Zan Fu
Format: Article
Language:English
Published: BMC 2024-09-01
Subjects:
Colorectal cancer
GCS1
Endoplasmic reticulum stress
GRP78
Deubiquitination
Online Access:https://doi.org/10.1186/s13046-024-03176-8

Internet

https://doi.org/10.1186/s13046-024-03176-8

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