Chicken GSDME, a major pore-forming molecule responsible for RNA virus-induced pyroptosis in chicken

ABSTRACT Pyroptosis is an inflammatory type of programmed cell death that mainly depends on the formation of plasma membrane pores by Gasdermin D (GSDMD) in mammals. However, the genetic deficiency of GSDMD in chicken renders avian pyroptosis elusive. Here, we show that infection of DF-1 cells (a ch...

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Bibliographic Details

Published in:	Journal of Virology
Main Authors:	Zhi Chen, He Chang, Shujun Zhang, Hui Gao, Li Gao, Hong Cao, Xiaoqi Li, Yongqiang Wang, Shijun J. Zheng
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-01-01
Subjects:	IBDV pyroptosis GSDME caspase-3 caspase-7
Online Access:	https://journals.asm.org/doi/10.1128/jvi.01588-24