Bile Acids Activate NLRP3 Inflammasome, Promoting Murine Liver Inflammation or Fibrosis in a Cell Type-Specific Manner

Bile acids (BA) as important signaling molecules are considered crucial in development of cholestatic liver injury, but there is limited understanding on the involved cell types and signaling pathways. The aim of this study was to evaluate the inflammatory and fibrotic potential of key BA and the ro...

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Bibliographic Details

Published in:	Cells
Main Authors:	Theresa Maria Holtmann, Maria Eugenia Inzaugarat, Jana Knorr, Lukas Geisler, Marten Schulz, Veerle Bieghs, Mick Frissen, Ariel E. Feldstein, Frank Tacke, Christian Trautwein, Alexander Wree
Format:	Article
Language:	English
Published:	MDPI AG 2021-10-01
Subjects:	sterile inflammation hepatic stellate cells Kupffer cells cholestasis inflammagens cholic acid
Online Access:	https://www.mdpi.com/2073-4409/10/10/2618