Progression of Osteosarcoma from a Non-Metastatic to a Metastatic Phenotype Is Causally Associated with Activation of an Autocrine and Paracrine uPA Axis.

Pulmonary metastasis is the major untreatable complication of osteosarcoma (OS) resulting in 10-20% long-term survival. The factors and pathways regulating these processes remain unclear, yet their identification is crucial in order to find new therapeutic targets. In this study we used a multi-omic...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Liliana Endo-Munoz, Na Cai, Andrew Cumming, Rebecca Macklin, Lilia Merida de Long, Eleni Topkas, Pamela Mukhopadhyay, Michelle Hill, Nicholas A Saunders
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2015-01-01
Online Access:	http://europepmc.org/articles/PMC4552671?pdf=render