DETexT: An SNV detection enhancement for low read depth by integrating mutational signatures into TextCNN

Detecting SNV at very low read depths helps to reduce sequencing requirements, lowers sequencing costs, and aids in the early screening, diagnosis, and treatment of cancer. However, the accuracy of SNV detection is significantly reduced at read depths below ×34 due to the lack of a sufficient number...

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Bibliographic Details

Published in:	Frontiers in Genetics
Main Author:	Tian Zheng
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-09-01
Subjects:	extra-low read depth variant detection TextCNN mutational signatures SNV
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2022.943972/full