The Janus Kinase Inhibitor Ruxolitinib Prevents Terminal Shock in a Mouse Model of Arenavirus Hemorrhagic Fever

Arenaviruses such as Lassa virus cause arenavirus hemorrhagic fever (AVHF), but protective vaccines and effective antiviral therapy remain unmet medical needs. Our prior work has revealed that inducible nitric oxide synthase (iNOS) induction by IFN-γ represents a key pathway to microvascular leak an...

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發表在:	Microorganisms
Main Authors:	Mehmet Sahin, Melissa M. Remy, Doron Merkler, Daniel D. Pinschewer
格式:	Article
語言:	英语
出版:	MDPI AG 2021-03-01
主題:	Arenavirus hemorrhagic fever LCMV Janus kinase JAK inhibitor Ruxolitinib nitric oxide
在線閱讀:	https://www.mdpi.com/2076-2607/9/3/564