BMP and Hedgehog Regulate Distinct AGM Hematopoietic Stem Cells Ex Vivo

Hematopoietic stem cells (HSC), the self-renewing cells of the adult blood differentiation hierarchy, are generated during embryonic stages. The first HSCs are produced in the aorta-gonad-mesonephros (AGM) region of the embryo through endothelial to a hematopoietic transition. BMP4 and Hedgehog affe...

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發表在:	Stem Cell Reports
Main Authors:	Mihaela Crisan, Parham Solaimani Kartalaei, Alex Neagu, Sofia Karkanpouna, Tomoko Yamada-Inagawa, Caterina Purini, Chris S. Vink, Reinier van der Linden, Wilfred van Ijcken, Susana M. Chuva de Sousa Lopes, Rui Monteiro, Christine Mummery, Elaine Dzierzak
格式:	Article
語言:	英语
出版:	Elsevier 2016-03-01
主題:	hematopoietic stem/progenitor cells HPSCs AGM BMP Hh VEGF development hematopoiesis
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2213671116000333