Elevation of effective p53 expression sensitizes wild-type p53 breast cancer cells to CDK7 inhibitor THZ1

Abstract Background The cyclin-dependent kinase 7 (CDK7) inhibitor THZ1 represses multiple cancer cells. However, its tumor-repressive efficiency in wild-type p53 breast cancer cells remains controversial. Methods We conducted various assays, including CCK8, colony formation, flow cytometry, western...

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發表在:	Cell Communication and Signaling
Main Authors:	Yueyuan Wang, Zhihao Zhang, Xuguang Mi, Mingxi Li, Dan Huang, Tingting Song, Xiaoyan Qi, Ming Yang
格式:	Article
語言:	英语
出版:	BMC 2022-09-01
主題:	CDK7 p53 GSDME THZ1 Breast cancer
在線閱讀:	https://doi.org/10.1186/s12964-022-00837-z