Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation

AimNumerous reports have demonstrated the key importance of macrophage-elicited metabolic inflammation in insulin resistance (IR). Our previous studies confirmed that hyperuricemia or high uric acid (HUA) treatment induced an IR state in several peripheral tissues to promote the development of type...

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الحاوية / القاعدة:	Frontiers in Immunology
المؤلفون الرئيسيون:	Hairong Zhao, Jiaming Lu, Furong He, Mei Wang, Yunbo Yan, Binyang Chen, De Xie, Chenxi Xu, Qiang Wang, Weidong Liu, Wei Yu, Yuemei Xi, Linqian Yu, Tetsuya Yamamoto, Hidenori Koyama, Wei Wang, Chenggui Zhang, Jidong Cheng
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Frontiers Media S.A. 2022-09-01
الموضوعات:	hyperuricemia insulin resistance of macrophage insulin signaling IRS2-proteasome degradation inflammatory macrophage
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.931087/full