Dynamic mechanisms and targeted interventions in cerebral ischemia–reperfusion injury: pathological cascade from ischemia to reperfusion and promising therapeutic strategies

Cerebral ischemia–reperfusion injury (CI/RI) is a critical event causing secondary neurological deterioration following vascular recanalization in patients with ischemic stroke (IS), involving multiple interrelated pathological processes that synergistically aggravate brain injury. However, the unde...

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Bibliographic Details

Published in:	Frontiers in Neuroscience
Main Authors:	Xufeng Meng, Zhi Zheng, Li Yang, Chen Yang, Xiaoli Li, Yunfei Hao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Subjects:	cerebral ischemia reperfusion injury (CI/RI) ischemic stroke (IS) pathologic process mitochondrial dysfunction inflammation
Online Access:	https://www.frontiersin.org/articles/10.3389/fnins.2025.1649533/full