Targeted complement inhibition using bispecific antibodies that bind local antigens and endogenous complement regulators

Complement activation protects against infection but also contributes to pathological mechanisms in a range of clinical conditions such as autoimmune diseases and transplant rejection. Complement-inhibitory drugs, either approved or in development, usually act systemically, thereby increasing the ri...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Haiyu Wang, Fleur S. van de Bovenkamp, Douwe J. Dijkstra, Leoni Abendstein, Nicole V. Borggreven, Jos Pool, Rob Zuijderduijn, Christoph Gstöttner, Kyra A. Gelderman, Timon Damelang, Gestur Vidarsson, Anna M. Blom, Elena Domínguez-Vega, Paul W. H. I. Parren, Thomas H. Sharp, Leendert A. Trouw
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-05-01
Subjects:	complement antibobies inhibition targeted autoimmunity
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1288597/full