Comparison of intranasal naloxone and intranasal nalmefene in a translational model assessing the impact of synthetic opioid overdose on respiratory depression and cardiac arrest

IntroductionUsing a validated translational model that quantitatively predicts opioid-induced respiratory depression and cardiac arrest, we compared cardiac arrest events caused by synthetic opioids (fentanyl, carfentanil) following rescue by intranasal (IN) administration of the μ-opioid receptor a...

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Bibliographic Details

Published in:	Frontiers in Psychiatry
Main Authors:	Celine M. Laffont, Prasad Purohit, Nash Delcamp, Ignacio Gonzalez-Garcia, Phil Skolnick
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-06-01
Subjects:	synthetic opioids fentanyl carfentanil cardiac arrest translational model opioid antagonists
Online Access:	https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1399803/full