Therapeutic potential of combined BRAF/MEK blockade in BRAF-wild type preclinical tumor models

Abstract Background Mounting evidence suggests that RAF-mediated MEK activation plays a crucial role in paradox MAPK (re)activation, leading to resistance and therapeutic failure with agents hitting a single step along the MAPK cascade. Methods We examined the molecular and functional effects of sin...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Journal of Experimental & Clinical Cancer Research
المؤلفون الرئيسيون: Anais Del Curatolo, Fabiana Conciatori, Ursula Cesta Incani, Chiara Bazzichetto, Italia Falcone, Vincenzo Corbo, Sabrina D’Agosto, Adriana Eramo, Giovanni Sette, Isabella Sperduti, Teresa De Luca, Mirko Marabese, Senji Shirasawa, Ruggero De Maria, Aldo Scarpa, Massimo Broggini, Donatella Del Bufalo, Francesco Cognetti, Michele Milella, Ludovica Ciuffreda
التنسيق: مقال
اللغة:الإنجليزية
منشور في: BMC 2018-07-01
الموضوعات:
MAPK
BRAF
MEK
Combination therapy
Paradoxical effect
الوصول للمادة أونلاين:http://link.springer.com/article/10.1186/s13046-018-0820-5

الانترنت

http://link.springer.com/article/10.1186/s13046-018-0820-5

مواد مشابهة