Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions

Genetic effects on gene expression and splicing can be modulated by cellular and environmental factors; yet interactions between genotypes, cell type, and treatment have not been comprehensively studied together. We used an induced pluripotent stem cell system to study multiple cell types derived fr...

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Bibliographic Details

Published in:	eLife
Main Authors:	Anthony S Findley, Alan Monziani, Allison L Richards, Katherine Rhodes, Michelle C Ward, Cynthia A Kalita, Adnan Alazizi, Ali Pazokitoroudi, Sriram Sankararaman, Xiaoquan Wen, David E Lanfear, Roger Pique-Regi, Yoav Gilad, Francesca Luca
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2021-05-01
Subjects:	allele specific expression GxE gene regulation cardiovascular disease IPSC regulatory variants
Online Access:	https://elifesciences.org/articles/67077