Cellular and extracellular proteomic profiling of paradoxical low-flow low-gradient aortic stenosis myocardium

AimsPatients with severe aortic stenosis (AS), low transvalvular flow (LF) and low gradient (LG) with normal ejection fraction (EF)—are referred to as paradoxical LF-LG AS (PLF-LG). PLF-LG patients develop more advanced heart failure symptoms and have a worse prognosis than patients with normal EF a...

Full description

Bibliographic Details

Published in:	Frontiers in Cardiovascular Medicine
Main Authors:	Manar Elkenani, Javier Barallobre-Barreiro, Moritz Schnelle, Belal A. Mohamed, Bo E. Beuthner, Christoph Friedemann Jacob, Niels B. Paul, Xiaoke Yin, Konstantinos Theofilatos, Andreas Fischer, Miriam Puls, Elisabeth M. Zeisberg, Ajay M. Shah, Manuel Mayr, Gerd Hasenfuß, Karl Toischer
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-09-01
Subjects:	paradoxical low-flow low-gradient aortic stenosis normal ejection fraction high-gradient aortic stenosis myocardial biopsies cellular and extracellular matrix proteomics transcatheter aortic valve implantation (TAVI)
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2024.1398114/full