Beta-amyloid influences the content and trafficking of beta-amyloid precursor protein via Na,K-ATPase-Src kinase positive feedback loop

Beta-amyloid (Aβ) is an important factor in the development of pathology in Alzheimer’s disease. Level of beta-amyloid precursor protein (APP) is increased in neurites with age and in Alzheimer’s disease model mice. However, it is unclear whether Aβ can affect APP levels in cells. The aim of this st...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Irina Y. Petrushanko, Denis R. Lisitskii, Filipp A. Filonov, Olga G. Leonova, Vladimir A. Mitkevich, Maria A. Strelkova, Alexander A. Makarov
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	beta-amyloid APP Src kinase ouabain APP trafficking Na,K-ATPase
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1665715/full