Role of Glyoxalase in Astrocytes’ Supportive Function Under Hyperglycemic Conditions: Aminoguanidine and Kir4.1 Channel Recovery

Background/Objectives: Diabetes mellitus is a metabolic disorder, and hyperglycemia results in abnormal brain function. Since glycolysis is the main energy pathway in glial cells, astrocytes possess a more developed glyoxalase (Glo) system than neurons and exhibit better survival. Glycolysis helps t...

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Bibliographic Details

Published in:	Brain Sciences
Main Authors:	Jadier Colón-Vázquez, Nathaly M. Rosado-Rivera, Joshua J. Navedo-Jackson, Arelys A. Angueira-Laureano, Yanitza Hernandez-Santiago, Geronimo Maldonado-Martinez, Miguel P. Méndez-González, Misty J. Eaton, Serguei N. Skatchkov, David E. Rivera-Aponte
Format:	Article
Language:	English
Published:	MDPI AG 2025-10-01
Subjects:	diabetes astrocytes glyoxalase system aminoguanidine Kir4.1 channels potassium uptake
Online Access:	https://www.mdpi.com/2076-3425/15/10/1075