Anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation

Abstract Alzheimer’s disease is a specific neurodegenerative disorder, distinct from normal aging, with a growing unmet medical need. It is characterized by the accumulation of amyloid plaques in the brain, primarily consisting of amyloid beta (Aβ) fibrils. Therapeutic antibodies can slow down the d...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Mookyoung Han, Benedikt Frieg, Dirk Matthes, Andrei Leonov, Sergey Ryazanov, Karin Giller, Evgeny Nimerovsky, Marianna Stampolaki, Kai Xue, Kerstin Overkamp, Christian Dienemann, Dietmar Riedel, Armin Giese, Stefan Becker, Bert L. de Groot, Gunnar F. Schröder, Loren B. Andreas, Christian Griesinger
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-10-01
Online Access:	https://doi.org/10.1038/s41467-025-64443-6