Adaptation of cell spreading to varying fibronectin densities and topographies is facilitated by β1 integrins

Cells mechanical behaviour in physiological environments is mediated by interactions with the extracellular matrix (ECM). In particular, cells can adapt their shape according to the availability of ECM proteins, e.g., fibronectin (FN). Several in vitro experiments usually simulate the ECM by functio...

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Bibliographic Details

Published in:	Frontiers in Bioengineering and Biotechnology
Main Authors:	Enrico Domenico Lemma, Zhongxiang Jiang, Franziska Klein, Tanja Landmann, Kai Weißenbruch, Sarah Bertels, Marc Hippler, Bernhard Wehrle-Haller, Martin Bastmeyer
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Subjects:	cell spreading cell signalling fibronectin integrin micropatterning
Online Access:	https://www.frontiersin.org/articles/10.3389/fbioe.2022.964259/full