Seroprevalence of binding and neutralizing antibodies against 18 adeno-associated virus types in patients with neuromuscular disorders

High levels of pre-existing antibodies are a major challenge for the application of viral vectors since they can severely limit their efficacy. To identify promising candidates among adeno-associated virus (AAV) based vectors for future gene therapies for the treatment of hereditary neuromuscular di...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Xiaoyan Wang, Patrick Julian Klann, Ellen Wiedtke, Yumi Sano, Nico Fischer, Lisa Schiller, Anna Elfert, Anne-Katrin Güttsches, Ute Weyen, Dirk Grimm, Matthias Vorgerd, Wibke Bayer
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-09-01
Subjects:	adeno-associated virus viral vector gene therapy neuromuscular disease seroprevalence neutralizing antibodies
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1450858/full