Histone H2A Lys130 acetylation epigenetically regulates androgen production in prostate cancer

Abstract The testicular androgen biosynthesis is well understood, however, how cancer cells gauge dwindling androgen to dexterously initiate its de novo synthesis remained elusive. We uncover dual-phosphorylated form of sterol regulatory element-binding protein 1 (SREBF1), pY673/951-SREBF1 that acts...

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出版年:	Nature Communications
主要な著者:	Thanh Nguyen, Dhivya Sridaran, Surbhi Chouhan, Cody Weimholt, Audrey Wilson, Jingqin Luo, Tiandao Li, John Koomen, Bin Fang, Nagireddy Putluri, Arun Sreekumar, Felix Y. Feng, Kiran Mahajan, Nupam P. Mahajan
フォーマット:	論文
言語:	英語
出版事項:	Nature Portfolio 2023-06-01
オンライン･アクセス:	https://doi.org/10.1038/s41467-023-38887-7