Polymorphisms in Inflammatory Genes Modulate Clinical Complications in Patients With Sickle Cell Disease

Sickle cell disease (SCD), the most common monogenic disease worldwide, is marked by a phenotypic variability that is, to date, only partially understood. Because inflammation plays a major role in SCD pathophysiology, we hypothesized that single nucleotide polymorphisms (SNP) in genes encoding func...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Karina Tozatto-Maio, Robert Girot, Indou Deme Ly, Ana Cristina Silva Pinto, Vanderson Rocha, Francisco Fernandes, Ibrahima Diagne, Yahia Benzerara, Carla L. Dinardo, Julia Pavan Soler, Simone Kashima, Itauá Leston Araujo, Chantal Kenzey, Guilherme H. H. Fonseca, Evandra S. Rodrigues, Fernanda Volt, Luciana Jarduli, Annalisa Ruggeri, Christina Mariaselvam, Sandra F. M. Gualandro, Hanadi Rafii, Barbara Cappelli, Felipe Melo Nogueira, Graziana Maria Scigliuolo, Renato Luiz Guerino-Cunha, Kelen Cristina Ribeiro Malmegrim, Belinda P. Simões, Eliane Gluckman, Ryad Tamouza
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-09-01
Subjects:	sickle cell retinopathy sickle cell disease inflammation markers NK cell receptors and ligands toll-like receptor (TLR) non-classical HLA
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2020.02041/full