Dysregulated inflammasome activity in intestinal inflammation – Insights from patients with very early onset IBD

Inflammatory bowel disease (IBD) is a multifactorial disorder triggered by imbalances of the microbiome and immune dysregulations in genetically susceptible individuals. Several mouse and human studies have demonstrated that multimeric inflammasomes are critical regulators of host defense and gut ho...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	David Illig, Daniel Kotlarz
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Subjects:	VEO-IBD inflammasome immunodeficiency pediatrics genetics inflammation
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1027289/full