Role of innate immunological/inflammatory pathways in myelodysplastic syndromes and AML: a narrative review

Abstract Dysregulation of the innate immune system and inflammatory-related pathways has been implicated in hematopoietic defects in the bone marrow microenvironment and associated with aging, clonal hematopoiesis, myelodysplastic syndromes (MDS), and acute myeloid leukemia (AML). As the innate immu...

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Bibliographic Details

Published in:	Experimental Hematology & Oncology
Main Authors:	Charan Thej Reddy Vegivinti, Praneeth Reddy Keesari, Sindhusha Veeraballi, Catarina Maria Pina Martins Maia, Ansh Krishnachandra Mehta, Rohit Reddy Lavu, Rahul Kumar Thakur, Sri Harsha Tella, Riya Patel, Venkata Kiranmayi Kakumani, Yashwitha Sai Pulakurthi, Srinivas Aluri, Ritesh Kumar Aggarwal, Nandini Ramachandra, Rongbao Zhao, Srabani Sahu, Aditi Shastri, Amit Verma
Format:	Article
Language:	English
Published:	BMC 2023-07-01
Subjects:	Myelodysplastic syndromes (MDS) Acute myeloid leukemia (AML) Innate Immune pathways Tumor microenvironment (TME) Toll like receptors (TLRs) IL1 receptor Associated kinase (IRAK)
Online Access:	https://doi.org/10.1186/s40164-023-00422-1