Pdgfrα deficiency in islet β-cells up-regulates apoptosis of beta-cells and disturbs glucose metabolism in B6 mice

IntroductionPancreatic β-cell dysfunction is a key contributor to the development of Type 2 Diabetes. The platelet-derived growth factor receptor α (PDGFRα) is known to play a crucial role in β-cell proliferation and expansion. However, its specific role in β-cell function and glucose metabolism rem...

Full description

Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Authors:	Luyao Zhang, Yanpeng Xing, Pai Wang, Jianlei Gu, Jian Peng, Juan Huang, James Alexander Pearson, Youjia Hu, Hongyu Zhao, F. Susan Wong, Li Wen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	obesity pancreatic beta cells PDGFR alpha apoptosis ATF5 Gadd45b
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2025.1630979/full